Interdisciplinary Complex Systems: Theoretical Physics Methods in Systems Biology

The group studies problems of nonlinear dynamics of complex systems focusing on biological problems using a theoretical physics approach.

Topics investigated by the group scientists are:
• Reaction-diffusion equations
• Turbulence in vortex dynamics
• Heat Transfer in excitable tissues
• Mechano-electric Feedback
• Computational Cardiology
• Stochastic systems in Biophysics
• Mathematical Models of Tumor Growth
• Fluid Dynamics in biological systems
• Complex Networks

Group leader: Prof. Simonetta Filippi (ICRANet and University Campus Bio-Medico, Italy)

Group members: Prof. Christian Cherubini (ICRANet and University Campus Bio-Medico, Italy), Alessio Gizzi (Researcher, University Campus Bio-Medico, Rome, Italy), Letizia Chiodo (Researcher, University Campus Bio-Medico, Rome, Italy), Alessandro Loppini (Researcher, University Campus Bio-Medico, Rome, Italy), Martina Nicoletti, (PhD student, University Campus Bio-Medico, Rome, Italy)

Recent relevant publications

1) Loppini A., Filippi S. and Stanley H. E. "Critical transitions in heterogeneous networks: Loss of low-degree nodes as an early warning signal", Phys. Rev. E, vol. 99, 040301(R) 5 pages (2019)

2) Loppini A., Gizzi A., Cherubini C., Cherry E.M.,Fenton F.H. and Filippi S. "Spatiotemporal correlation uncovers characteristic lengths in cardiac tissue", Phys. Rev. E, vol. 100 , 020201(R) 5 pages (2019)

3) Loppini A., Gizzi A., Ruiz-Baier R., Cherubini C., Fenton F.H. and Filippi S., "Competing Mechanisms of Stress-Assisted Diffusivity and Stretch-Activated Currents in Cardiac Electromechanics" (2018), Frontiers in Physiology, Volume 9, article 1714

4) Loppini A., Cherubini C., Filippi S., "On the emergent dynamics and synchronization of b-cells networks in response to space-time varying glucose stimuli" (2018), Chaos, Solitons and Fractals, 09 p.269 - 279

5) Boccia E., Gizzi A., Cherubini C., Nestola M.G.C., Filippi S., "Viscoelastic computational modeling of the human head-neck system: Eigenfrequencies and time-dependent analysis" (2018), Int J Numer Meth Biomed Engng. 34:e2900.